张红星，工学博士，北京农学院教授，2005年博士毕业于中国农业大学食品科学与营养工程学院，北京长城学者，北京市优秀人才，北京食品学会副理事长。

主要从事食品营养健康研究及功能性食品开发，围绕益生菌及其发酵产物干预慢病作用机制及其生产关键工程技术，先后主持完成国家、省部和企业横向项目40余项，研究成果获得授权国家发明专利30余项，发表科研论文80余篇，其中SCI收录论文30余篇，相关专利技术与企业签署成果转化协议20余项，研究成果获得省部级科研成果奖、教学成果奖4项。

一、联系方式

E-mail：hxzhang511@163.com

二、学习工作经历

1993-1999 黑龙江省卫生防疫站

1999-2002 哈尔滨商业大学 食品科学硕士研究生

2002-2005 中国农业大学 食品科学博士研究生

2007-2009 中国农业大学 生物学博士后

2005-至今 北京农学院 教授

三、研究领域及具体方向

食品生物技术、食品微生物发酵与功能产物、食品安全检测与控制

四、规划教材

①“十四五”省部级规划教材：《现代食品微生物学》 副主编

②“十一五”国家级规划教材：《现代食品微生物学》 副主编

③北京市精品教材: 《现代食品微生物实验技术》 副主编

五、授权国家发明专利

六、制定相关标准

国家行业标准《食品中赭曲霉毒素的测定方法》（2009B164）

七、部分代表性科研论文

1. Zhang HX, Liu L, Hao YF, Zhong SQ, Liu H, Han T, Xie YH*. Isolation and partial characterization of a bacteriocin produced by Lactobacillus plantarum BM-1 isolated from a traditionally fermented Chinese meat product. Microbiol Immunol, 2013,57(11): 746-55.

2. Zhang Hongxing, Rui Yu-Kui*. Determining mineral elements in four kinds of grains from Beijing market by ICP-MS simultaneously. Journal of Saudi Chemical Society, 2012, 16, 31-33.

3. Zhang Hongxing, Rui Yu-Kui*.Determination of Trace Elements, Heavy Metals and Rare Earth Elements in Corn Seeds from Beijing. E-Journal of Chemistry, E-Journals of Chemistry , 2011, 8(2), 782-786.

4. Hongxing Zhang, Yanling Hao, Dapeng Zhang, Yunbo Luo*. Characterization of the cryptic plasmid pTXW from Lactobacillus paracasei TXW. Plasmid, 2011, 65 (2011) : 1-7.

5. Hongxing Zhang, Benzhong Zhu, Yunbo Luo, Yuanhong Xie*. Functional Research of Ethylene Response Factor LeERF1 in the Disease Reaction of Tomato Fruit. First International Conference on Cellular, Molecular Biophysics and Bioengineering, 2010, 5, 348-353.

6. Hongxing Zhang, Li Liu, Guoxin Teng, Yuanhong Xie, Yong Liu, Hui Liu *. Expression of Bovine Chymosin Gene CYM in E. coli and the Activity Research of Milk-Clotting. First International Conference on Cellular, Molecular Biophysics and Bioengineering, 2010, 5, 361-364.

7. Hongxing Zhang, Nian Wang, Benzhong Zhu, Yuanhong Xie, Yunbo Luo, Shijie Yan, Tao Han. Effect of ACO gene silencing on the ethylene biosynthetic in peach. First International Conference on Cellular, Molecular Biophysics and Bioengineering, 2010, 5, 449-454.

8. Hongxing Zhang, Li Liu, Yuanhong Xie, Xiangning Chen. The Resarch of Physicochemical Characteristics for Bacteriocin Produced by Lactobacillus plantarum LF-1. First International Conference on Cellular, Molecular Biophysics and Bioengineering, 2010, 5, 455-459.

9. Hongxing Zhang, Li Liu, Yuanhong Xie, Lixia Xiong, Hui Liu. The Bacteriostasis characteristics research for bacteriocin produced by Lactobacillus plantarum LH-09. First International Conference on Cellular, Molecular Biophysics and Bioengineering, 2010, 5, 460-464.

10. Hongxing Zhang, Yu-kui Rui. Nutritional composition of the speciality ‘frozen pear’ from the Northeastern of China. Journal of Consumer Protection and Food Safety, 2010, 9: 345–346.

11. Zhang Hongxing, Xu Fang, Rui Yukui. Simultaneous Determination of Content of Ten Heavy Metals in Detergents from China by ICP-MS. Asian Journal of Chemistry, 2010, 22(6): 4777-4780.

12. Hongxing Zhang, Benzhong Zhu, Yunbo Luo, Yuanhong Xie*. The Research of Subcelluar Localization of Ethylene Signal Transcription Factor LeERF1 in tomato fruit. First International Conference on Cellular, Molecular Biophysics and Bioengineering, 2010, 5, 194-199.

13. Zhang Hongxing, Zhu Benzhong, Yu Bianyun, Hao Yanling, Fu Daqi, Xu Wentao & Luo Yunbo*. Cloning and DNA-binding properties of ethylene response factor, LeERF1 and LeERF2, in tomato. Biotechnology Letters, 2005. 27: 423–428.

14. Wenbo Liu, Shuai Zhang, Chang Chen, Junhua Jin, Hui Liu, Zheng Bian, Wenjing Qi, Yuanhong Xie, Hongxing Zhang*. Development of a visual detection method for Salmonella based on loop-mediated isothermal amplification using pyrophosphatase. FEMS Microbiol Lett. 2023, 370:fnad040.

15. He Wang, Junhua Jin, Xiaona Pang, Zheng Bian, Jingxin Zhu, Yanling Hao, Hongxing Zhang*, Yuanhong Xie*. Plantaricin BM-1 decreases viability of SW480 human colorectal cancer cells by inducing caspase-dependent apoptosis. Front Microbiol. 2023, 13:1103600.

16. Zheng Bian, Wenbo Liu, Junhua Jin, Yanling Hao, Linshu Jiang, Yuanhong Xie*, Hongxing Zhang*. Rcs phosphorelay affects the sensitivity of Escherichia coli to plantaricin BM-1 by regulating biofilm formation. Front Microbiol. 2022, 13:1071351.

17. Zheng Bian, Wenbo Liu, Junhua Jin, Yanling Hao, Linshu Jiang, Yuanhong Xie*, Hongxing Zhang*. Development of a recombinase polymerase amplification assay with lateral flow dipstick (RPA-LFD) for rapid detection of Shigella spp. and enteroinvasive Escherichia coli. PLoS One. 2022, 17(12):e0278869.

18. Yifei Liu, Yawen Wang, Xinyue Chen, Junhua Jin, Hui Liu, Yanling Hao, Hongxing Zhang*, Yuanhong Xie*. BasS/BasR Two-Component System Affects the Sensitivity of Escherichia coli to Plantaricin BM-1 by Regulating the Tricarboxylic Acid Cycle. Front Microbiol. 2022, 13:874789.

19. Jianjun Yang, Chenyang Dong, Fazheng Ren, Yuanhong Xie, Hui Liu, Hongxing Zhang*, Junhua Jin*. Lactobacillus paracasei M11-4 isolated from fermented rice demonstrates good antioxidant properties in vitro and in vivo. J Sci Food Agric. 2022, 102(8):3107-3118

20. Xinyue Chen, Yifei Liu, Junhua Jin, Hui Liu, Yanling Hao, Hongxing Zhang*, Yuanhong Xie*. YbfA Regulates the Sensitivity of Escherichia coli K12 to Plantaricin BM-1 via the BasS/BasR Two-Component Regulatory System. Front Microbiol. 2021,12:659198.

21. Yuanxiang Pang, Jianjun Yang, Xinyue Chen, Yu Jia, Tong Li, Junhua Jin, Hui Liu, Linshu Jian, Yanling Hao, Hongxing Zhang*, Yuanhong Xie*. An Antifungal Chitosanase from Bacillus subtilis SH21.Molecules. 2021 Mar 25;26(7):1863.

22. Junhua Jin, Linxia Jie, Hanwei Zhang, Yuanhong Xie, Hui Liu, Xiuzhi Gao, Hongxing Zhang*. Pediocin AcH Is Transcriptionally Regulated by a Two-Component System in Lactobacillus plantarum subsp. plantarum. J Food Prot. 2020;83(10):1693-1700.

23. Wang H, Xie YH, Zhang HW, Jin JH, Zhang HX*. Quantitative proteomic analysis reveals the influence of plantaricin BM-1 on metabolic pathways and peptidoglycan synthesis in Escherichia coli K12. PLoS One, 2020,15(4):e0231975. doi: 10.1371/journal.pone.0231975

24. Yang W, Xie Y, Jin J, Liu H, Zhang H*. Development and Application of an Active Plastic Multilayer Film by Coating a Plantaricin BM-1 for Chilled Meat Preservation. J Food Sci. 2019 Jul;84(7):1864-1870.

25. Xie Y, Zhang M, Gao X, Shao Y, Liu H, Jin J, Yang W, Zhang H*. Development and antimicrobial application of plantaricin BM-1 incorporating a PVDC film on fresh pork meat during cold storage. J Appl Microbiol. 2018 Oct;125(4):1108-1116.

26. Zhou HM, Xie YH, Liu H, Jin JH, Duan HX, Zhang HX*. Effects of two application methods of plantaricin BM-1 on control of Listeria monocytogenes and background spoilage bacteria in sliced vacuum-packaged cooked ham stored at 4 degrees. J Food Prot. 2015, 78(10):1835-41.

27. Huimin Zhou, Hongxing Zhang*,Yuanhong Xie, Tingting Zhou, Hui Liu, Yunbo Luo. Optimiation of Liquid Fermentation Conditions and Encapsulation for Nattokinase Production. Advanced Materials Research, Vols. 781-784 (2013) 1403-1409.

28. Lijuan Yu, Li Liu, Hongxing Zhang*, Yuanhong Xie, Hui Liu, Baohua Kong, Yunbo Luo. Effect of Bactericine as a Treatment for the Control of Listeria monocytogenes in Refrigerated Meat Products. Advanced Materials Research, Vols. 781-784 (2013) pp:1322-1327.

29. Lijuan Yu, Hongxing Zhang*,Yuanhong Xie, Siming Ma, Hui Liu, Yunbo Luo. Optimization of Fermentation Conditions for Higher Monacolin K Production by Monascus purpureus. Advanced Materials Research, Vols. 781-784 (2013), pp: 1397-1402.

30. Yuanhong Xie, Hui Liu, Hongxing Zhang*. Prokaryotic Expression and Purification of Tomato Cnr Protein. Advanced Materials Research, Vols. 690-693 (2013) , pp: 1247-1251.

31. Na Jia, Yuanhong Xie, Hongxing Zhang*. Effect of bacteriocin treatment on storage and quality of postharvest strawberry fruit, Advanced Materials Research, 2012，554：1547-1552.

32. Yang Yang, Hongxing Zhang*, Jingyu Gao, et al. Determination of Natural Occurrence of Ochratoxin A in Naked Oats of China by HPLC, Asian Journal of Chemistry, 2012, 24（11）: 5349-5351.

33. Hui Liu, Yuanhong Xie, Hongxing Zhang*. Studies on the Action mechanism for Cholesterol-lowering of Lactobacter which yields Bile Salt Hydrolase from Kefir Grains. First International Conference on Cellular, Molecular Biophysics and Bioengineering, 2010, 6, 204-209.

34. Hui Liu, Yuanhong Xie, Hongxing Zhang*. Effect and mechanism of cholesterol-lowering by Kluyveromyces from Tibetan Kefir. First International Conference on Cellular, Molecular Biophysics and Bioengineering, 2010, 2: 440-446.

35. Yuanhong Xie, Benzhong Zhu, Yunbo Luo, Hongxing Zhang*. Preparation of Polyclonal antibody and expression analysis of Gr in tomato r. First International Conference on Cellular, Molecular Biophysics and Bioengineering, 2010, 4, 476-482.

36. Hui Liu, Ruiqiong Wang, Ke Ding, Shuhan Xing, Shuang Han, Hongxing Zhang*. Purification and Structure Study on Exopolysaccharides Produced by Lactobacillus casei KL1 from Tibetan Kefir. First International Conference on Cellular, Molecular. Biophysics and Bioengineering, 2010, 5, 219-226.

37. 张红星，刘丽，刘慧. 乳酸菌中抗李斯特细菌素的筛选及理化性质分析.食品工业科技，2011，32（10）：231-238.

38. 张红星，刘丽，谢英. 风干肠中戊糖片球菌所产细菌素L5-6的理化特性研究.中国食品学报，2011，11（1）：75-79.

39. 张红星，王廿，刘勇，等. 乳酸菌胆盐水解酶生理特性和分子生物学的研究进展，食品科学，2011，32（11）：302-305.

40. 张红星，刘丽，谢远红，刘慧. 产细菌素戊糖片球菌的筛选及其细菌素的理化性质研究. 现代食品科技，2011，27（2）：135-138.

41. 张红星，韩景丽，陈静文，黄漫青，张馨如. 人工合成氯霉素抗原免疫血清效价的比较及多克隆抗体的制备. 中国农学通报，2010，26（6）：43-46.

42. 张红星，王廿，韩涛*.抑制ACC合酶和ACC氧化酶对植物贮藏保鲜的影响，食品科学，2009，24（9）：266-268.

43. 张红星，高美琴，张馨如，刘慧*. 丙烯酰胺人工抗原的合成及其多克隆抗体的制备，中国农学通报，2009，24（16）：91-93.

44. 张红星，朱本忠，张文，罗云波*.番茄乙烯信号转录因子LeERF1多克隆抗体制备及应用.中国食品学报，2008，8（1）：55-59.

45. 刘丽，郝彦玲，张红星*. 肉制品中产细菌素乳酸菌的分离及鉴定. 中国农学通报，2011，27（2）：424-428.

46. 刘丽，郝彦玲，张红星*. 1 株产细菌素植物乳杆菌的筛选及所产细菌素的理化性质分析.中国食品学报，2011，11（6）：47-52.

47. 惠明，刘勇，张红星*. 产胆盐水解酶BSH乳酸菌的鉴定及发酵条件优化.中国食品学报，2011，11（1）：214-221.

48. 刘慧，王世平，冉冉，张红星*. 藏灵菇源酸奶复合菌发酵剂对肠道菌群平衡的作用.中国食品学报，2011，11（6）：7-12.

49. 刘慧，周茉，张红星*.昆明酸浆米粉优势乳酸菌筛选及发酵性能研究.中国粮油学报，2011，26（5）：1-6.

50. 高璟瑜，杨扬，张红星*.抗赭曲霉毒素A多克隆抗体的制备. 现代食品科技，2011，27（3）：324-327.

51. 刘慧，董瑞婷，潘昌莉，高秀芝，张红星*. 克鲁维酵母菌产胆盐水解酶发酵条件的优化研究.中国酿造，2010，220（7）：44-46.

52. 刘慧，李晨，杨磊，贾慧，张红星*. 藏灵菇酵母菌K1耐胃肠道逆环境特性及降胆固醇的研究.中国酿造，2010，222（9）：61-64.

53. 刘慧，周末，熊丽霞，张红星*. 昆明酸浆米粉中优良乳酸杆菌筛选及复合发酵剂的研制.中国酿造，2010，223（10）：106-110.

54. 刘慧，何欢，熊丽霞，张红星*. 藏灵菇源克鲁维酵母K1菌株胆盐水解酶的特性研究.中国酿造，2010，224（11）：69-73.

55. 刘慧，王世平，冉冉，张红星*. 藏灵菇源酸奶复合菌发酵剂对大鼠肝脏胆固醇的作用.中国食品学报，2010，10（2）：35-39.

56. 刘慧，王世平，冉冉，张红星*.藏灵菇源酸奶复合菌发酵剂对大鼠脂质过氧化的影响.中国食品学报，2010，10（3）：27-32.

57. 刘慧，丁轲，王瑞琼，单冬雪，张红星*.应用高效液相色谱分析藏灵菇源乳酸菌发酵液中的四碳二羧酸.中国食品学报，2010，11（6）：47-52.

58. 刘慧，陈湘宁，李晨，杨磊，张红星*. 藏灵菇酵母菌M3耐胃肠道逆环境特性及降胆固醇的实验研究，中国农学通报，2009，24（15）: 68-71.

59. 滕国新，张红星*. 干酪产品的营养保健作用及其消费情况，中国食物与营养，2009，12（8）：45-47.

60. 刘慧，何欢，张雪娇，潘昌莉，张红星*. 蔵灵菇源克鲁维酵母M3菌株胆盐水解酶的特性研究，中国农学通报，2009，24（24）：112-117.

61. 刘慧，熊丽霞，张红星*.藏灵菇干酪乳杆菌KL1高产胞外多糖发酵条件的优化研究，中国农学通报，2008, 24(11) ：117-121.

62. 刘慧，熊丽霞，张红星*.藏灵菇源干酪乳杆菌KL1高产胆盐水解酶发酵条件的优化研究，食品科学，2008，24（12）：114-118.

63. 艾启俊，于庆华，张红星*.鹿蹄草素对金黄色葡萄球菌的抑制作用及其机理研究，中国食品学报，2007，7（2）：33-37.

64. 艾启俊，于庆华，张红星*. PCR技术检测编码绿脓杆菌外毒素A基因，中国食品学报，2006，6（6）：117-120.

65. 刘慧，杜薇，张红星*. 乳酸乳球菌乳酸亚种高产胆盐水解酶发酵条件的优化研究，食品科学，2006，27（11）：322-326.

66. Wang H, Zhang HX, Zhang HW, Jin JH, Xie YH. Outer Membrane Channel Protein TolC Regulates Escherichia coli K12 Sensitivity to Plantaricin BM-1 via the CpxR/CpxA Two-Component Regulatory System. Probiotics Antimicrob Proteins, 2020 Jun 11. doi: 10.1007/s12602-020-09671-6.

67. Wu SQ, Zhang HX, Zhou HM, Jin JH, Xie YH*. Synergistic effect of plantaricin BM-1 combined with physicochemical treatments on the control of Listeria monocytogenes in cooked ham. J Food Prot, 2017 Jun; 80(6):976-981.

68. Linxia Jie, Hongxing Zhang, Junchao Zhang, Junhua Jin, Hui Liu, Yuanhong Xie. Characterization of Four Novel Plasmids from Lactobacillus plantarum BM4. Jundishapur J Microbiol. 2017 November; 10(11):e12894.

69. Xie YH, Zhang HX, Liu H^*, Xiong LX, Gao XZ, Jia H, Lian ZX, Tong NS, Han T. Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat. Braz J Microbiol. 2015, 46(2):389-95.

70. Caicai Chen, Jiayi Li, Hongxing Zhang, Yuanhong Xie, Lixia Xiong, Hui Liu, Fang Wang. Effects of a probiotic on the growth performance, intestinal flora, and immune function of chicks infected with Salmonella pullorum. Poult Sci. 2020, 99(11):5316-5323.

71. Zhang M, Gao XZ, Zhang HX, Liu H, Jin JH, Yang WG, Xie YH^*. Development and anti-listerial activityof PE-based biological preservative films incorporating plantaricin BM-1. FEMS Microbiol Lett. 2017 Apr 1; 364(7).

72. Zhong SQ, Liu H, Zhang HX, Han T, Jia H, Xie YH*. Effects of Kluyveromyces marxianus isolated from Tibetan Mushroomsn on the plasma lipids, egg cholesterol level, egg quality and intestinal health of laying hens. Rev Bras Cienc Avic. 2016, 18:261-7.

73. Y.Hao, L.Zhao, H.Zhang, Z.Zhai, Y.Huang, X.Liu, and L.Zhang. Identification of the bacterial biodiversity in koumiss by denaturing gradient gel electrophoresis and species-specific polymerase chain reaction. Journal of Dairy Science, 2010, 93: 1926-1933.

74. Yan Zhang, Jingsheng Ma, Nanqing Jing, Hongxing Zhang, Yuanhong Xie, Hui Liu, Xiangfen Shan, Jianhua Ren, Junhua Jin. Bifidobacterium animalis A12 and Lactobacillus salivarius M18-6 Alleviate Alcohol Injury by keap1-Nrf2 Pathway and Thioredoxin System. Foods. 2023,12(3):439.

75. Yiming Wang, Jiayi Li, Yuanhong Xie, Hongxing Zhang, Junhua Jin, Lixia Xiong, Hui Liu. Effects of a probiotic-fermented herbal blend on the growth performance, intestinal flora and immune function of chicks infected with Salmonella pullorum. Poult Sci. 2021 Jul;100(7):101196.

76. Jin JH, Song J, Ren FZ, Zhang HX, Xie YH, Ma J, Li X. Investigation of Growth Phase-Dependent Acid Tolerance in Bifidobacteria longum BBMN68. Curr Microbiol. 2016 Nov;73(5):660-7.

77. Nanqing Jing, Fudong Liu, Ran Wang, Yan Zhang, Jianjun Yang, Yubing Hou, Hongxing Zhang, Yuanhong Xie, Hui Liu, Shaoyang Ge and Junhua Jin. Both live and heat-killed Bifidobacterium animalis J-12 alleviated oral ulcers in LVG golden Syrian hamsters by gavage by directly intervening in the intestinal flora structure. Food Funct. 2023, 14(4):2045-2058.

78. Yan Zhang, Yubing Hou, Shunliang Zhang, Nanqing Jing, Hongxing Zhang, Yuanhong Xie, Hui Liu, Jianguo Yan, Jianhua Ren, Junhua Jin. Bifidobacterium animalis A12, a Probiotic Strain That Promotes Glucose and Lipid Metabolism, Improved the Texture and Aroma of the Fermented Sausage. Foods. 2023, 12(2):336.

79. Jianjun Yang, Yumeng Ma, Tong Li, Yuanxiang Pang, Hongxing Zhang, Yuanhong Xie, Hui Liu, Yanfang Sun, Jianhua Ren, Junhua Jin. Ameliorative Effects of Bifidobacterium animalis subsp. lactis J-12 on Hyperglycemia in Pregnancy and Pregnancy Outcomes in a High-Fat-Diet/Streptozotocin-Induced Rat Model. Nutrients. 2022, 15(1):170.

80. Jin JH, Qin Q, Guo HY, Liu S, Ge S, Zhang HX, Cui J, Ren FZ*. Effect of Pre-Stressing on the Acid-Stress Response in Bifidobacterium Revealed Using Proteomic and Physiological Approaches. PLoS ONE, 2015, 10(2):e0117702.